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US 2025/0027946 A1Published application
Detection, quantification and/or isolation of circulating tumor cells based on the expression of cd321 marker
OwnerCédric BLANPAIN, Panagiota SOTIROPOULOU +1inventors
InventorsCédric BLANPAIN, Panagiota SOTIROPOULOU, Ievgenia PASTUSHENKO
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Abstract
The application discloses CD321 as a useful global marker of circulating tumor cells (CTCs) and provides related methods and kits of parts relying on detection of CD321.
Claims20
1-24. (canceled)
A kit comprising:
- one or more agents capable of specifically binding to CD321;
- and
- one or more agents capable of specifically binding to at least one pan-leukocyte marker
- and/or one or more agents capable of specifically binding to at least one thrombocyte marker.
1 more element
A method for diagnosing cancer, comprising:
- identifying a subject as having circulating non-hematopoietic cells that express CD321.
A method of treatment, comprising:
- identifying circulating non-hematopoietic cells that express CD321 in a subject, wherein the circulating non-hematopoietic cells are cancer cells;
- and
- administering a cancer treatment to the subject.
Dependencies are inferred from the claim text.