Flow cytometry-based platform for the detection, enumeration, and isolation of disseminated tumor cells in bone marrow aspirates
AssigneeThe Trustees of the University of Pennsylvania
InventorsLewis Chodosh, Elizabeth Chislock
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Abstract
The present invention provides compositions and methods for detecting and isolating disseminated tumor cells (DTCs) from breast cancer in a bone marrow aspirate of a subject. The invention further provides methods of treating breast cancer in the subject.
Claims18
1-42. (canceled)
A method of detecting a disseminated tumor cell (DTC) in a sample from a subject comprising the steps of contacting the sample with at least one labeled molecule that specifically binds to at least one marker selected from the group consisting of EpCAM, CD45, and CD43, and analyzing the sample.
A composition for detecting a disseminated tumor cell (DTC) in a sample from a subject comprising at least one labeled molecule that specifically binds to at least one marker selected from the group consisting of EpCAM, CD45, and CD43.
Dependencies are inferred from the claim text.