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US 2025/0027940 A1Published application
Isolation and Diagnostics of Fetal Cells
AssigneeArcedi Biotech ApS
InventorsRipudaman Singh, Palle Schelde Jensen
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to methods of fetal cell isolation and methods of prenatal diagnostics. The disclosure furthermore provides novel markers for fetal cell isolation that can be used to isolate fetal cells for prenatal diagnostics.
Claims21
1-84. (canceled)
A method of prenatal diagnostics comprising the steps of:
- a. isolating a fetal amnion or chorion cell obtained from a maternal blood sample, wherein the maternal blood sample is from a woman between gestational ages 15 and 20 weeks, comprising the steps of:
- i. contacting the cells comprised in the maternal blood sample with a ligand directed against a fetal amnion or chorion cell marker;
- ii. enriching the maternal blood sample for fetal cells before or after step a.i;
- iii. detecting the fetal amnion or chorion cell;
- and
- iv. isolating the fetal amnion or chorion cell using FACS, or manual or automated cell picking;
- b. diagnosing the fetus by analysing a genotype or a phenotype of the fetal amnion or chorion cell.
4 more elements
A method of detecting a fetal amnion or chorion cell comprising the steps of:
- a. contacting the cells comprised in a maternal blood sample obtained from a woman between the gestational ages 15 and 20 weeks with a ligand towards a fetal amnion or chorion cell marker;
- b. enriching the cells comprised in said maternal blood sample before or after step a, and
- c. and detecting the fetal amnion or chorion cell marker, thereby detecting the fetal amnion or chorion cell.
Dependencies are inferred from the claim text.