Methods and compositions related to alcohol use or complications therefrom
OwnerRobert Philibert, Allan M. Anderseninventors
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Abstract
This document describes materials and methods for determining whether or not an individual will suffer from severe alcohol withdrawal syndrome or complications therefrom, or seizures related to alcohol withdrawal. This document also describes materials and methods for determining whether or not an individual presenting with myocardial infarction (MI) or acute coronary syndrome is suffering from heavy alcohol consumption (HAC) or alcohol use disorder (AUD).
Claims21
A method of determining whether or not an individual will suffer from severe alcohol withdrawal syndrome or complications therefrom, comprising the steps of:
- determining the methylation status of CpG site cg07375256 in a biological sample from the individual;
- wherein the methylation status of the at least one CpG dinucleotide identifies individuals that will suffer from severe alcohol withdrawal syndrome or complications therefrom.
A method of determining whether an individual presenting with myocardial infarction (MI) or acute coronary syndrome (ACS) is suffering from heavy alcohol consumption (HAC) or alcohol use disorder (AUD), comprising the steps of:
- determining the alcohol T score (ATS) (i.e., average of 4 Zscores for cg02583484, cg04987734, cg09935388 and cg04583842) for the individual;
- and
- determining the methylation status of CpG site cg07375256 in a biological sample from the individual
- wherein the ATS and the methylation status of CpG site cg07375256 are indicative of whether an individual presenting with MI or ACS is suffering from HAC or AUD.
Dependencies are inferred from the claim text.