Methods and Compositions for Assessing Patients with Preeclampsia-Related Conditions Using MicroRNA
AssigneeEwinger, Inc.
InventorsEdward E. WINGER, Jane REED
Life of this patent
Estimating the term…
Abstract
The invention is directed to methods and compositions for collecting a non-placental biological samples of cells and quantifying and comparing levels of expression of microRNAs to characterize a preeclampsia-related condition. The samples may be collected before or after an intervention or may be collected over a period of time. One of the samples may be a control sample. Patients may then be treated according to their response.
Claims9
1-22. (canceled)
A diagnostic kit for characterizing a preeclampsia-related condition comprising a microarray including at least four microRNAs selected from the group consisting of hsa-miR-7-5p, hsa-miR-16, hsa-miR-148a-3p, hsa-miR-199-5p, hsa-miR-210, hsa-miR-301a-3p, and hsa-miR-223, hsa-miR-575, and hsa-miR-582-5p;
- and instructions for comparing the expression of one or more of the at least four microRNAs quantified using a biological sample derived from one or more maternal blood cells of a pregnant human being to the expression of the same one or more miRNAs in a control sample, wherein determination of an increase in the expression of the one or more miRNAs in the pregnant human being relative to the control sample indicates the pregnant human being is at risk of developing a preterm birth.
Dependencies are inferred from the claim text.