Method for detecting neurodegenerative disease using short-chain rna

Abstract

Disclosed is a method that enables detection of whether or not a subject is affected by a neurodegenerative disease, which method is simpler and more effective than conventional methods. This method includes the steps of: (a) preparing an extracellular vesicle fraction from a body fluid sample of the subject; (b) counting the number of extracellular vesicles contained in the extracellular vesicle fraction obtained in Step (a), to obtain the number of the extracellular vesicles; (c) measuring the total amount of short-chain RNA contained in all extracellular vesicles counted in Step (b), to obtain the total amount of short-chain RNA per extracellular vesicle; and (d) judging the subject as being affected by the neurodegenerative disease in a case where the total amount of short-chain RNA per extracellular vesicle obtained in Step (c) is larger than a total amount of short-chain RNA per extracellular vesicle obtained from a body fluid sample of a healthy individual.

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