Compositions and methods for inducing esr1, pi3k, her2, and her3 immune responses
AssigneeReplicate Bioscience, Inc.
InventorsNathaniel Stephen WANG, Shigeki Joseph MIYAKE-STONER, Parinaz ALIAHMAD
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Abstract
The present disclosure relates to the field of molecular virology, and particularly relates to nucleic acid molecules encoding a modified equine encephalitis virus viral genome or self-replicating RNA (srRNA) construct, pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting an immune response in a subject in need thereof, as well as methods for preventing and/or treating cancer.
Claims30
A nucleic acid construct comprising a nucleic acid sequence encoding a modified Eastern Equine Encephalitis virus (EEEV) genome or self-replicating RNA (srRNA), wherein at least a portion of the nucleic acid sequence encoding the viral structural proteins of the modified EEEV genome or srRNA has been replaced by a coding sequence for a polypeptide construct comprising:
- a) a coding sequence for estrogen receptor 1 (ESR1) or a variant thereof;
- b) a coding sequence for PI3K or a variant thereof;
- c) a coding sequence for HER2 or a variant thereof and
- d) a coding sequence for HER3 or a variant thereof.
Dependencies are inferred from the claim text.