Production of d-lysergic acid
AssigneesNational University of Singapore, Imperial College Innovations Limited
InventorsWei Jie Garrett WONG, Li Rong LIM, Maybelle Darlene Kho GO, Wen Shan YEW, Paul S. FREEMONT, David John BELL
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Abstract
Modified cells suitable for the production of ergot alkaloids include engineered recombinant cells having one or more genes that code for one or more enzymes in the biosynthetic pathway from tryptophan to D-lysergic acid (DLA). Methods of culturing the engineered recombinant cells can be used for the production of DLA and other ergot alkaloids.
Claims26
An isolated recombinant cell comprising one or more genes selected from the group consisting of dmaW, easF, easC, easE, easD, easAisomerase, and cloA, wherein each gene codes for an enzyme from the biosynthetic pathway from tryptophan to D-lysergic acid (DLA).
2-3. (canceled)
11-31. (canceled)
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An isolated recombinant cell comprising at least one dmaW, at least one easF, at least one easE or easC, at least one easD, at least one easAisomerase or easG, and at least one cloA gene.
An isolated recombinant cell comprising at least one dmaW, at least one easF, at least one easE, at least one easD, at least one easAisomerase, and at least one cloA gene.
An isolated recombinant cell comprising at least one dmaW, at least one easF, at least one easC, at least one easD, at least one easAisomerase, at least one easG, and at least one cloA gene.
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45-49. (canceled)
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Dependencies are inferred from the claim text.