Double stranded rna targeting proprotein convertase subtilisin kexin 9 (pcsk9) and methods of use thereof

An isolated oligonucleotide comprising a sense strand and an antisense strand, wherein:

• the sense strand comprises a nucleotide sequence that is substantially identical to a region between the nucleotide positions 3543 to 3596, from the 5′ end of a Proprotein convertase subtilisin/kexin type 9 (PCSK9) mRNA sequence according to SEQ ID NO:
• 1,
• and the antisense strand is substantially complementary to the sense strand such that the sense strand and the antisense strand together form a double stranded region.