Staggered triple lipid-modified nucleic acid compounds

A compound having the structure:

• wherein
• A is a nucleic acid;
• L4 and L6 are independently a bond, —NH—, —O—, —S—, —C(O)—, —NHC(O)—, —NHC(O)NH—, —C(O)O—, —OC(O)—, —C(O)NH—, —OPO2—O—, —OP(S)(O)—O—, —OP(S)2—O—, —S(O)2NH—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene or substituted or unsubstituted heteroarylene;
• L5 is independently a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene or substituted or unsubstituted heteroarylene;
• L7 is independently a bond, substituted or unsubstituted alkylene or substituted or unsubstituted heteroalkylene;
• L1 is independently a bond, substituted or unsubstituted 2 to 50 membered heteroalkylene or L1A-L1B-L1C-L1D-L1E;
• L2 is independently a bond, substituted or unsubstituted 2 to 50 membered heteroalkylene or L2A-L2B-L2C-L2D-L2E;
• L3 is independently a bond, substituted or unsubstituted 2 to 50 membered heteroalkylene or L3A-L3B-L3C-L3D-L3E;
• L1A, L1B, L1C, L1D, L1E, L2A, L2B, L2C, L2D, L2E, L3A, L3B, L3C, L3D and L3E are independently a bond, —NH—, —O—, —S—, —C(O)—, —NHC(O)—, —S(O)2C(O)—, —OPO2—O—, —OP(S)(O)—O—, —OP(S)2—O—, —S(O)NH—, —NHC(O)NH—, —C(O)O—, —OC(O)—, —C(O)NH—, substituted or unsubstituted C1-C25 alkylene, substituted or unsubstituted 2 to 25 membered heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene or substituted or unsubstituted heteroarylene,
• wherein L1A-L1B-L1C-L1D-L1E is not a bond, substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene with a terminal carbon atom and at least one of L1A, L1B, L1C, L1D or L1E is not a bond or substituted or unsubstituted 2 to 25 membered heteroalkylene,
• wherein L2A-L2B-L2C-L2D-L2E is not a bond, substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene with a terminal carbon atom and at least one of L2A, L2B, L2C, L2D or L2E is not a bond or substituted or unsubstituted 2 to 25 membered heteroalkylene,
• wherein L3A-L3B-L3C-L3D-L3E is not a bond or substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene with a terminal carbon atom at least one of L3A, L3B, L3C, L3D or L3E is not a bond or substituted or unsubstituted 2 to 25 membered heteroalkylene;
• R1, R2 and R3 are independently unsubstituted C1-C25 alkyl;
• and
• t is an integer from 1 to 5,
• provided that when L1 and L2 are —NH(CO)—, and L3 and L1 is —(CH2)4—NH(CO)—, then at least one of R1, R2, and R3 are not unsubstituted C15 alkyl;
• and when L1 and L1 are —NH(CO)—, and L2 and L3 is —(CH2)4—NH(CO)—, then at least one of R1, R2, and R3 are not unsubstituted C15 alkyl.