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OwnerVeenu AISHWARYA, Brian Wayne HUNTER +1inventors
InventorsVeenu AISHWARYA, Brian Wayne HUNTER, Kirsten STELINSKI
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The present invention is based on the seminal discovery that FANA antisense oligonucleotides inhibit the growth of bacteria harbored within plant-feeding insects, wherein the insect is chewing or feeding from the xylem, phloem, or mesophyll. Specifically, the use of FANA antisense oligonucleotides decreases the expression of target RNA or DNA and inhibits growth of CLas within the psyllid D. citri, which then prevents the transmission of CLas from D. citri to a citrus tree, or of CLso within the psyllid Bactericera cockerelli which prevents the transmission of CLso from Bactericera cockerelli to a Solanaceous plant. Specifically, the use of FANA antisense oligonucleotides decreases the expression of target RNA or DNA and inhibits growth of CLas within the host plant, citrus or Solanaceous, which then prevents the transmission of CLas from D. citri to a citrus tree, or which prevents the transmission of CLso from Bactericera cockerelli to a Solanaceous plant.
A method of decreasing target RNA or DNA expression in a plant-chewing or piercing-sucking plant-feeding insect, comprising providing an antisense oligonucleotide to the insect, or a member of its microbiome, wherein the oligonucleotide comprises at least one 2′-deoxy-2′-fluoroarabinonucleotide (2′F-ANA)-modified nucleotide and at least one 2′-deoxyribonucleotide.
A method of inhibiting bacterial growth in a plant-chewing or piercing-sucking plant-feeding insect comprising providing an antisense oligonucleotide to the insect or to its microbiome,
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A method of preventing and/or managing of huanglongbing disease in a citrus tree or plant or preventing and/or managing a Liberibacter zebra chip disease in Solanaceous plant comprising providing an antisense oligonucleotide to a plant chewing or piercing-sucking plant-feeding insect or to its microbiome, wherein the oligonucleotide binds to a target RNA or DNA,
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Dependencies are inferred from the claim text.