Rna encoding peptidoglycan hydrolase and use thereof for treating bacterial infection
OwnerUgur Sahin, Andreas Henning +5inventors
InventorsUgur Sahin, Andreas Henning, Stephanie Erbar, Stefan Albrecht Schille, Anna Spier, Lorenzo Corsini, Zehra Visram
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Abstract
The invention provides agents and methods for treating bacterial infections using RNA. The RNA encoding peptidoglycan hydrolases. e.g., endolysins, is formulated and administered in a way that peptidoglycan hydrolase proteins. e.g., endolysin proteins, can be produced and secreted by cells of a subject to combat bacterial infections.
Claims25
1-119. (canceled)
A composition or medical preparation comprising RNA encoding an amino acid sequence comprising a peptidoglycan hydrolase.
A method of treating bacterial infection in a subject comprising administering RNA encoding an amino acid sequence comprising a peptidoglycan hydrolase to the subject.
Dependencies are inferred from the claim text.