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US 2025/0027042 A1Published application
Rapid T-Cell Manufacturing
AssigneeKure.AI, Inc.
InventorDavid Wald
Life of this patent
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Abstract
The present disclosure provides methods for rapid manufacture of a genetically modified immune effector cell such as a T-cell. The methods allow rapid (<1day) production of genetically modified immune effector cells such as CAR T-cells.
Claims21
A method for rapid manufacture of a genetically modified T-cell population, comprising:
- obtaining a mixed mononuclear cell population;
- and
- substantially simultaneously:
- exposing a T-cell population comprised in the mixed mononuclear cell population to a T-cell activation agent;
- and
- exposing the mixed mononuclear cell population to a viral vector adapted to transduce at least the T-cell population comprised in the mixed mononuclear cell population with a foreign nucleotide.
3 more elements
Dependencies are inferred from the claim text.