US 2025/0026859 A1Published application

Anti-DXd Antibodies and Methods of Use

AssigneeBeiGene, Ltd.

InventorsDan Li, Xiaoyan Tang, Charng-Sheng Tsai, Mei-Hsuan Tsai

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The present disclosure provides antigen-binding fragments thereof that bind to DXd, and use of the antibody for detection and assay of DXd.

Dependent claims

An antibody or antigen-binding fragment thereof, comprising:

(i) a heavy chain variable region that comprises (a) a HCDR1 (Heavy Chain Complementarity Determining Region 1) of SEQ ID NO:
11, (b) a HCDR2 of SEQ ID NO:
12 and (c) a HCDR3 of SEQ ID NO:
13 and a light chain variable region that comprises:
(d) a LCDR1 (Light Chain Complementarity Determining Region 1) of SEQ ID NO:
14, (e) a LCDR2 of SEQ ID NO:
15, and (f) a LCDR3 of SEQ ID NO:
16;
(ii) a heavy chain variable region that comprises (a) a HCDR1 of SEQ ID NO:
1, (b) a HCDR2 of SEQ ID NO:
2 and (c) a HCDR3 of SEQ ID NO:
3;
and a light chain variable region that comprises:
(d) a LCDR1 of SEQ ID NO:
4, (e) a LCDR2 of SEQ ID NO:
5, and (f) a LCDR3 of SEQ ID NO:
6;
(iii) a heavy chain variable region that comprises (a) a HCDR1 of SEQ ID NO:
21, (b) a HCDR2 of SEQ ID NO:
22 and (c) a HCDR3 of SEQ ID NO:
23;
and a light chain variable region that comprises:
(d) a LCDR1 of SEQ ID NO:
24, (e) a LCDR2 of SEQ ID NO:25, and (f) a LCDR3 of SEQ ID NO:
26;
(iv) a heavy chain variable region that comprises (a) a HCDR1 of SEQ ID NO:
31, (b) a HCDR2 of SEQ ID NO:
32 and (c) a HCDR3 of SEQ ID NO:
33;
and a light chain variable region that comprises:
(d) a LCDR1 of SEQ ID NO:
34, (e) a LCDR2 of SEQ ID NO:35, and (f) a LCDR3 of SEQ ID NO:
36;
or
(v) a heavy chain variable region that comprises (a) a HCDR1 of SEQ ID NO:
41, (b) a HCDR2 of SEQ ID NO:
42 and (c) a HCDR3 of SEQ ID NO:
43;
and a light chain variable region that comprises:
(d) a LCDR1 of SEQ ID NO:
44, (e) a LCDR2 of SEQ ID NO:45, and (f) a LCDR3 of SEQ ID NO:
46.

39 more elements

Dependencies are inferred from the claim text.

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