Mini bodies as vaccines for hiv
AssigneePomona Ricerca S.r.l.
InventorsMassimo CLEMENTI, Roberto BURIONI, Roberta Antonia DIOTTI
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Abstract
The present invention relates to an anti-idiotype minibody capable of specifically binding the idiotype of a human anti-gp120 antibody and capable of evoking an anti-gp120 immune response. The present invention also relates to immunogenic compositions including such minibody and the use thereof in the therapeutic or prophylactic treatment of HIV infection or related diseases.
Claims14
An anti-idiotype minibody comprising:
- a scFV sequence capable of specifically binding the idiotype of a human anti-gp120 antibody, wherein said scFv comprises the variable domain of the heavy chain (VH) linked to the variable domain of the light chain (VL) with a linker sequence;
- a hinge sequence;
- and
- a IgG CH3 domain.
The minibody according to, for use in the therapeutic or prophylactic treatment of HIV infection or related diseases, in particular by inducing a neutralizing immune response against HIV.
Dependencies are inferred from the claim text.