Back to results
US 2025/0026846 A1Published application
Novel Anti-Human Transferrin Receptor Antibody Capable of Penetrating Blood-Brain Barrier
AssigneeJCR Pharmaceuticals Co., Ltd.
InventorsHiroyuki Sonoda, Kenichi Takahashi
Life of this patent
Estimating the term…
Abstract
Provided is an anti-human transferrin receptor antibody or an analog thereof, wherein in the heavy chain variable region of the antibody, (a) CDR1 comprises the amino acid sequence set forth as SEQ ID NO: 62 or SEQ ID NO: 63, (b) CDR2 comprises the amino acid sequence set forth as SEQ ID NO: 13 or SEQ ID NO: 14, and (c) CDR3 comprises the amino acid sequence set forth as SEQ ID NO: 15 or SEQ ID NO: 16, and an analogue thereof.
Claims6
A fusion protein of an anti-human transferrin receptor antibody and human heparan N-sulfatase, wherein the antibody is Fab antibody, and wherein
- (1) the light chain of the antibody comprises the amino acid sequence set forth as SEQ ID NO:
- 23, and
- (2) the heavy chain of the antibody is linked, on the C-terminus of the heavy chain and via the amino acid sequence consisting of three consecutively linked amino acid sequences each set forth as SEQ ID NO:
- 3, to the human heparan N-sulfatase, thereby forming the amino acid sequence set forth as SEQ ID NO:
- 128.
2 more elements
Dependencies are inferred from the claim text.