Antibody binding to fcrn for treating autoimmune diseases

A polynucleotide encoding an isolated anti-FcRn antibody or antigen-binding fragment, the polynucleotide comprising:

• (i) a first portion encoding a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID No:
• 33;
• (ii) a second portion encoding a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID No:
• 34;
• (iii) a third portion encoding a heavy chain variable region CDR3 comprising the amino acid sequence of SEQ ID No:
• 35;
• (iv) a fourth region encoding a light chain variable region CDR1 comprising the amino acid sequence of SEQ ID No:
• 36;
• (v) a fifth region encoding a light chain variable region CDR2 comprising the amino acid sequence of SEQ ID No:
• 37;
• and
• (vi) a sixth region encoding a light chain variable region CDR3 comprising the amino acid sequence of SEQ ID No:
• 38.

A polynucleotide encoding an isolated anti-FcRn antibody or antigen-binding fragment, the polynucleotide comprising:

• (i) a first portion encoding a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID No:
• 39;
• (ii) a second portion encoding a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID No:
• 40;
• (iii) a third portion encoding a heavy chain variable region CDR3 comprising the amino acid sequence of SEQ ID No:
• 41;
• (iv) a fourth region encoding a light chain variable region CDR1 comprising the amino acid sequence of SEQ ID No:
• 42;
• (v) a fifth region encoding a light chain variable region CDR2 comprising the amino acid sequence of SEQ ID No:
• 43;
• and
• (vi) a sixth region encoding a light chain variable region CDR3 comprising the amino acid sequence of SEQ ID No:
• 44.