Combination therapies of hdac inhibitors and pd-1 inhibitors
AssigneeHUYABIO International, LLC
InventorsReid P. Bissonnette, Alain Rolland, Mireille Gillings
Life of this patent
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Abstract
Provided herein are combinations that include an HDACi and a PD-1 inhibitor that are useful for treating cancer, including reducing and/or preventing cancer metastasis. The combination is also useful for treating cancer that has been previously treated with a PD-L1 inhibitor.
Claims9
A method of treating cancer in a subject, wherein the cancer comprises non-small cell lung cancer, melanoma, breast cancer, or renal cell carcinoma, the method comprising administering to the subject an HDAC inhibitor and a PD-1 inhibitor, wherein the PD-1 inhibitor comprises an anti-PD-1 antibody and the HDAC inhibitor comprises HBI-8000:
Dependencies are inferred from the claim text.