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US 2025/0026831 A1Published application
Methods of treating colorectal cancer
AssigneeBristol-Myers Squibb Company
InventorMichael AXELSON
Life of this patent
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Abstract
This disclosure provides methods for treating a tumor derived from a colorectal cancer exhibiting a high degree of microsatellite instability in a subject comprising administering to the subject an anti-PD-1 antibody. In some embodiments, the method further comprises administering an anti-CTLA-4 antibody. In some embodiments, the colorectal cancer is rectal cancer, colon cancer, or any combination thereof.
Claims23
A method of treating a subject afflicted with a tumor derived from a colorectal cancer, comprising administering to the subject:
- (i) an anti-PD-1 antibody, and
- (ii) an anti-CTLA-4 antibody:
- wherein the tumor exhibits a high degree of microsatellite instability (“MSI-H”).
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Dependencies are inferred from the claim text.