Cd79a chimeric antigen receptors

A chimeric antigen receptor (CAR) comprising:

• a) an extracellular domain that comprises an anti-CD79A antibody, or antigen binding fragment thereof, that binds a human CD79A polypeptide;
• wherein the anti-CD79A antibody, or antigen binding fragment thereof, comprises a variable light chain sequence comprising complementarity-determining region (CDR) sequences CDRL1-CDRL3 set forth in SEQ ID NOs:
• 1-3, and a variable heavy chain sequence comprising CDRH1-CDRH3 sequences set forth in SEQ ID NOs:
• 4-6;
• and wherein the variable heavy chain is positioned c-terminal to the variable light chain;
• b) a CD8α hinge region;
• c) a CD8α transmembrane domain;
• d) a 4-1BB (CD137) intracellular co-stimulatory signaling domain;
• and
• e) a CD3ζ primary signaling domain.