US 2025/0026827 A1Published application

Anti-SIRP-Beta1 Antibodies and Methods of Use Thereof

AssigneeAlector LLC

InventorsAndrew Pincetic, Patricia Culp, Arnon Rosenthal

Life of this patent

Estimating the term…

Abstract

The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a SIRPβ1 polypeptide, e.g., a human SIRPβ1, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Claims25

Dependent claims

-104. (canceled)

An isolated antibody that binds to human SIRPβ1, wherein the antibody comprises a heavy chain variable region comprising HVR-H1, HVR-H2, and HVR-H3 and a light chain variable region comprising HVR-L1, HVR-L2, and HVR-L3, wherein the antibody is a bispecific antibody or an antibody-drug conjugate, and wherein:

a) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
31, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
80, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
101, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
125;
b) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
31, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
228, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
238, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
125;
c) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
31, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
229, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
239, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
125;
d) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
31, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
229, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
240, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
125;
e) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
31, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
229, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
241, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
125;
f) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
32, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
81, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
102, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
126;
g) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
32, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
230, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
242, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
126;
h) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
32, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
231, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
243, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
126;
i) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
32, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
232, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
244, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
126;
j) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
32, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
99, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
245, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
126;
k) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
32, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
230, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
242, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
253;
l) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
19, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
37, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
85, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
107, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
131;
m) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
19, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
37, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
233, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
246, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
131;
n) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
19, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
37, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
234;
HVR-H2 comprises the amino acid sequence of SEQ ID NO:
247, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
131;
o) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
19, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
37, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
233, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
248, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
131;
p) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
19, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
37, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
233, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
246, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
254;
q) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
2, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
22, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
69, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
97, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
121, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
163;
r) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
2, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
22, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
69, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
235, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
249, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
163;
s) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
2, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
22, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
69, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
236, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
250, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
163;
t) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
2, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
22, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
69, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
237, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
251, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
163;
u) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
2, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
22, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
69, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
236, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
252, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
163;
v) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
2, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
17, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
33, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
82, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
103, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
127;
w) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
34, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
83, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
104, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
128;
x) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
2, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
17, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
33, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
82, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
105, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
129;
y) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
35, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
80;
HVR-H2 comprises the amino acid sequence of SEQ ID NO:
101, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
125;
z) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
3, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
18, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
36, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
84, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
106, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
130;
aa) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
3, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
18, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
38, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
86, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
104, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
132;
bb) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
4, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
20, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
39, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
484, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
108, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
133;
cc) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
5, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
20, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
40, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
87, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
108, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
134;
dd) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
6, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
21, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
41, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
82, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
109, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
135;
ee) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
5, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
20, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
42, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
88, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
110, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
136;
ff) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
2, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
22, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
43, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
84, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
106, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
137;
gg) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
7, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
23, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
44, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
89, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
111, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
44138;
hh) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
3, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
18, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
45, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
84, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
112, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
139;
ii) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
3, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
18, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
46, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
83, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
104, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
140;
jj) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
4, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
20, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
47, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
484, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
108, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
141;
kk) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
4, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
20, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
48, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
484, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
108, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
142;
ll) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
8, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
18, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
49, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
84, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
112, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
143;
mm) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
4, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
20, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
50, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
90, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
104, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
144;
nn) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
9, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
24, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
51, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
91, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
113, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
145;
oo) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
7, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
23, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
52, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
84, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
114, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
146;
pp) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
6, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
25, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
53, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
92, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
107, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
147;
qq) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
9, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
23, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
54, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
93, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
108, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
148;
rr) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
4, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
20, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
55, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
84, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
108, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
149;
ss) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
3, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
18, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
56, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
84, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
108, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
150;
tt) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
383, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
57, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
94, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
115, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
151;
uu) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
4, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
20, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
58, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
84, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
112, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
152;
vv) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
10, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
59, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
95, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
116, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
153;
ww) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
9, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
23, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
60, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
96, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
117, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
154;
xx) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
8, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
18, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
61, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
88, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
118, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
155;
yy) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
11, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
26, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
62, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
91, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
119, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
156;
zz) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
6, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
25, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
63, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
82, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
120, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
157;
aaa) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
4, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
20, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
64, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
84, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
108, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
158;
bbb) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
9, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
23, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
65, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
96, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
121, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
159;
ccc) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
2, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
17, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
66, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
87, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
108, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
160;
ddd) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
9, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
23, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
67, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
96, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
121, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
161;
eee) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
7, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
27, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
68, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
92, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
107, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
162;
fff) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
12, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
26, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
70, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
94, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
111, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
164;
ggg) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
7, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
28, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
71, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
83, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
104, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
165;
hhh) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
2, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
29, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
72, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
92, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
107, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
166;
iii) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
13, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
30, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
73, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
91, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
122, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
167;
jjj) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
10, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
74, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
92, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
107, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
168;
kkk) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
14, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
16, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
75, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
80, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
123, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
169;
lll) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
11, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
26, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
76, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
98, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
111, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
170;
mmm) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
15, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
23, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
77, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
99, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
124, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
171;
nnn) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
12, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
26, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
78, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
100, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
111, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
172;
or
ooo) HVR-L1 comprises the amino acid sequence of SEQ ID NO:
3, HVR-L2 comprises the amino acid sequence of SEQ ID NO:
18, HVR-L3 comprises the amino acid sequence of SEQ ID NO:
79, HVR-H1 comprises the amino acid sequence of SEQ ID NO:
84, HVR-H2 comprises the amino acid sequence of SEQ ID NO:
108, and HVR-H3 comprises the amino acid sequence of SEQ ID NO:
173.

469 more elements

Dependencies are inferred from the claim text.

Facts

Application: 18/756,198Filed 27 Jun 2024
Priority: 29 Jun 2018
Published: 23 Jan 2025
Term ends: Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61P 25/28
Drugs for disorders of the nervous system: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents,…
C07K 16/2803
Against receptors, cell surface antigens or cell surface determinants: against the immunoglobulin superfamily
A61P 35/00
Antineoplastic agents
A61K 2039/505
Medicinal preparations containing antigens or antibodies: comprising antibodies

Family

Application62/691,913Us provisional application · filed 29 Jun 2018
Application17/256,508Continuation · filed 28 Dec 2020
Application18/756,198Continuation
US 12,060,422 B2Related patent
US 2021/0277113 A1Published application
US 2025/0026827 A1This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

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