Methods of treating or preventing a complication of sickle cell disease

A method for treating or preventing or delaying progression or reducing or inhibiting or hindering development of a complication associated with sickle cell disease in a subject suffering from sickle cell disease, wherein the complication associated with sickle cell disease affects the cardiovascular system, the method comprising administering to the subject a protein comprising an antigen binding domain of an antibody that specifically binds to granulocyte colony stimulating factor (G-CSF) receptor (G-CSFR) and inhibits G-CSF signaling, wherein the antigen binding domain comprises:

• (i) a heavy chain variable region (VH) comprising an amino acid sequence set forth in SEQ ID NO:
• 4 and a light chain variable region (VL) comprising an amino acid sequence set forth in SEQ ID NO:
• 5;
• and/or
• (ii) a VH comprising a complementarity determining region (CDR)1 comprising a sequence set forth in SEQ ID NO:
• 6;
• a CDR2 comprising a sequence set forth in SEQ ID NO:
• 7;
• and a CDR3 comprising a sequence set forth in SEQ ID NO:
• 8;
• and a VL comprising a CDR1 comprising a sequence set forth in SEQ ID NO:
• 9;
• a CDR2 comprising a sequence set forth in SEQ ID NO:
• 10;
• and a CDR3 comprising a sequence set forth in SEQ ID NO:
• 11.