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US 2025/0026807 A1Published application
Immune Cell Binding Polypeptides
AssigneeCue Biopharma, Inc.
InventorAnish Suri
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Abstract
The present disclosure provides immune cell binding polypeptides (ICBPs) that include a binding moiety that can bind to ILT2 and/or ILT4 polypeptides, at least one immunoinhibitory polypeptide, and a scaffold polypeptide. The ICBPs are useful for inducing immunological tolerance. The present disclosure provides methods of inducing immunological tolerance.
Claims30
An immune cell binding polypeptide (ICBP) comprising:
- a) a binding moiety comprising an HLA-G molecule and a stabilizing peptide;
- b) at least one immunoinhibitory polypeptide;
- and
- c) a scaffold polypeptide
- wherein the HLA-G molecule comprises an HLA-G heavy chain polypeptide and a β2M polypeptide, and
- wherein the binding moiety can bind to ILT2 and/or ILT4 polypeptides on an immune cell, and
- wherein the ICBP can suppress the activity of the immune cell.
4 more elements
Dependencies are inferred from the claim text.