Novel proteins
AssigneeDucentis Biotherapeutics Limited
InventorsRebecca ASHFIELD, Philip HUXLEY
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Abstract
The invention relates generally to mutant CD200 proteins which bind with greater affinity to the CD200 receptor than wild-type CD200, in particular the invention relates to a mutated CD200 protein comprising specific mutations at amino acid residue position 130 and/or 131. This invention also relates to a fusion protein comprising the protein as defined herein fused to a non-CD200 protein portion directly or via an optional linker portion, a pharmaceutical composition comprising the protein as defined herein and uses thereof.
Claims23
A mutated CD200 protein comprising the following mutations:
- (i) K130F;
- or
- (ii) I131F;
- or
- (iii) K130F and I131F;
- or
- (iv) K130F and I131Y;
- or
- (v) K130Y and I131F.
A polypeptide comprising a mutated CD200 protein comprising at least 90% identity to:
- (SEQ ID NO:
- 26)
- QVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFS
- ENHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCLFNTFGF
- GKISGTACLTVYVQPIVSLHYKFSEDHLNITCSATARPAPMVFWKVPRS
- GIENSTVTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFK
- QTVNK
- with the following mutations at positions 130 and/or 131:
- (i) K130F;
- or
- (ii) I131F;
- or
- (iii) K130F and I131F;
- or
- (iv) K130F and I131Y;
- or
- (v) K130Y and I131F.
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.