Method of reducing bispecific t cell engager or chimeric antigen receptor t cell mediated cytokine release syndrome using interleukins-4, -10, or a fusion protein thereof

A method of reducing the severity of bispecific T cell engager (BiTE) or chimeric antigen receptor T cell (CAR-T) therapy induced cytokine release syndrome (CRS) during malignant disease treatment and enhancing tumor cytolysis comprising administering to a patient in need thereof an amount of a composition comprising a dual cytokine fusion protein of Formula II

• NH2-(Y)-(X1)-(Zn)-(X2)-(Y)-COOH (Formula II)
• wherein
• “Y” is a monomer of IL10 or an variant thereof;
• “X” is a VL or VH region from a first monoclonal antibody;
• “X2” is a VH or VL region from the first monoclonal antibody;
• wherein when X1 is a VL, X2 is a VH or when X1 is a VH, X2 is a VL,
• wherein the first monoclonal antibody is an anti-ebola antibody;
• wherein the VL and VH from the anti-ebola antibody include 3 light chain CDRs and 3 heavy chain CDRs that are engrafted with 3 light chain CDRs and 3 heavy chain CDRs from a second monoclonal antibody;
• “Z” is a cytokine other than IL-10;
• “n” is an integer of 1;
• and
• wherein:
• i. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, and Z is IL-2;
• ii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-15;
• iii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-7;
• iv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-28;
• v. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-29;
• vi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-EGFR monoclonal antibody, and Z is IFN-α;
• vii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-21;
• viii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-2;
• ix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-15;
• x. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-7;
• xi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-28;
• xii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-29;
• xiii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER2 monoclonal antibody, and Z is IFN-α;
• xiv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-21;
• xv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-2;
• xvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-15;
• xvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-7;
• xviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-28;
• xix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-29;
• xx. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IFN-α;
• xxi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-21;
• xxii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-2;
• xxiii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-15;
• xxiv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-7;
• xxv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-28;
• xxvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-29;
• xxvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IFN-α;
• xxviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-21;
• xxix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-2;
• xxx. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-15;
• xxxi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-7;
• xxxii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-28;
• xxxiii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-29;
• xxxiv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IFN-α;
• xxxv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-21;
• xxxvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-2;
• xxxvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-15;
• xxxviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-7;
• xxxix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-28;
• xl. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-29;
• xli. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IFN-α;
• xlii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-21;
• xliii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-2;
• xliv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-15;
• xlv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-7;
• xlvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-28;
• xlvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-29;
• xlviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD19 monoclonal antibody, and Z is IFN-α;
• xlix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-21;
• l. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-2;
• li. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-15;
• lii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-7;
• liii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-28;
• liv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-29;
• lv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD20 monoclonal antibody, and Z is IFN-α;
• lvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-21;
• lvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-2;
• lviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-15;
• lix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-7;
• lx. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-28;
• lxi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-29;
• lxii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD22 monoclonal antibody, and Z is IFN-α;
• lxiii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-21;
• lxiv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-2;
• lxv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-15;
• lxvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-7;
• lxvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-28;
• lxviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-29;
• lxix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PSMA monoclonal antibody, and Z is IFN-α;
• lxx. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-21;
• lxxi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-2;
• lxxii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-15;
• lxxiii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-7;
• lxxiv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-28;
• lxxv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-29;
• lxxvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CEA monoclonal antibody, and Z is IFN-α;
• lxxvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-21;
• lxxviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-2;
• lxxix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-15;
• lxxx. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-7;
• lxxxi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-28;
• lxxxii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-29;
• lxxxiii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-BCMA monoclonal antibody, and Z is IFN-α;
• lxxxiv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-21;
• lxxxv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-2;
• lxxxvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-15;
• lxxxvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-7;
• lxxxviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-28;
• lxxxix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-29;
• xc. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IFN-α;
• xci. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-21;
• xcii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD33 monoclonal antibody, and Z is IL-2;
• xciii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD33 monoclonal antibody, and Z is IL-15;
• xciv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD33monoclonal antibody, and Z is IL-7;
• xcv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD33 monoclonal antibody, and Z is IL-28;
• xcvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD33 monoclonal antibody, and Z is IL-29;
• xcvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD33 monoclonal antibody, and Z is IFN-α;
• xcviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD33 monoclonal antibody, and Z is IL-21;
• xcix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-2;
• c. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-15;
• ci. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-7;
• cii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-28;
• ciii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-29;
• civ. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IFN-α;
• cv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-21;
• cvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-2;
• cvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-15;
• cviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-7;
• cix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-28;
• cx. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-29;
• cxi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IFN-α;
• cxii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-21;
• cxiii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-2;
• cxiv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-15;
• cxv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-7;
• cxvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-28;
• cxvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-29;
• cxviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IFN-α;
• cxix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-21;
• cxx. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-2;
• cxxi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-15;
• cxxii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-7;
• cxxiii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-28;
• cxxiv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-29;
• cxxv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GD2 monoclonal antibody, and Z is IFN-α;
• cxxvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-21;
• cxxvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-2;
• cxxviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-15;
• cxxix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-7;
• cxxx. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-28;
• cxxxi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-29;
• cxxxii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-5T4 monoclonal antibody, and Z is IFN-α;
• cxxxiii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-21;
• cxxxiv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-2;
• cxxxv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-15;
• cxxxvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-7;
• cxxxvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-28;
• cxxxviii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-29;
• cxxxix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER3 monoclonal antibody, and Z is IFN-α;
• cxl. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-21;
• cxli. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-2;
• cxlii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-15;
• cxliii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-7;
• cxliv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-28;
• cxlv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-29;
• cxlvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-EGFR monoclonal antibody, and Z is IFN-α;
• cxlvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-21;
• cxlviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-2;
• cxlix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-15;
• cl. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-7;
• cli. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-28;
• clii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-29;
• cliii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER2 monoclonal antibody, and Z is IFN-α;
• cliv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-21;
• clv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-2;
• clvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-15;
• clvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-7;
• clviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-28;
• clix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-29;
• clx. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IFN-α;
• clxi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-21;
• clxii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-2;
• clxiii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-15;
• clxiv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-7;
• clxv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-28;
• clxvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-29;
• clxvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IFN-α;
• clxviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-21;
• clxix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-2;
• clxx. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-15;
• clxxi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-7;
• clxxii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-28;
• clxxiii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-29;
• clxxiv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IFN-α;
• clxxv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-21;
• clxxvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-2;
• clxxvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-15;
• clxxviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-7;
• clxxix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-28;
• clxxx. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-29;
• clxxxi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IFN-α;
• clxxxii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-21;
• clxxxiii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-2;
• clxxxiv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-15;
• clxxxv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-7;
• clxxxvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-28;
• clxxxvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-29;
• clxxxviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD19 monoclonal antibody, and Z is IFN-α;
• clxxxix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-21;
• cxc. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-2;
• cxci. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-15;
• cxcii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-7;
• cxciii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-28;
• cxciv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-29;
• cxcv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD20 monoclonal antibody, and Z is IFN-α;
• cxcvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-21;
• cxcvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-2;
• cxcviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-15;
• cxcix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-7;
• cc. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-28;
• cci. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-29;
• ccii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD22 monoclonal antibody, and Z is IFN-α;
• cciii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-21;
• cciv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-2;
• ccv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-15;
• ccvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-7;
• ccvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-28;
• ccviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-29;
• ccix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PSMA monoclonal antibody, and Z is IFN-α;
• ccx. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-21;
• ccxi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-2;
• ccxii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-15;
• ccxiii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-7;
• ccxiv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-28;
• ccxv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-29;
• ccxvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CEA monoclonal antibody, and Z is IFN-α;
• ccxvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-21;
• ccxviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-2;
• ccxix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-15;
• ccxx. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-7;
• ccxxi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-28;
• ccxxii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-29;
• ccxxiii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-BCMA monoclonal antibody, and Z is IFN-α;
• ccxxiv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-21;
• ccxxv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-2;
• ccxxvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-15;
• ccxxvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-7;
• ccxxviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-28;
• ccxxix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-29;
• ccxxx. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IFN-α;
• ccxxxi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-21;
• ccxxxii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD33 monoclonal antibody, and Z is IL-2;
• ccxxxiii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD33 monoclonal antibody, and Z is IL-15;
• ccxxxiv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD33monoclonal antibody, and Z is IL-7;
• ccxxxv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD33 monoclonal antibody, and Z is IL-28;
• ccxxxvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD33 monoclonal antibody, and Z is IL-29;
• ccxxxvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD33 monoclonal antibody, and Z is IFN-α;
• ccxxxviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD33 monoclonal antibody, and Z is IL-21;
• ccxxxix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-2;
• ccxl. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-15;
• ccxli. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-7;
• ccxlii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-28;
• ccxliii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-29;
• ccxliv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IFN-α;
• ccxlv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-21;
• ccxlvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-2;
• ccxlvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-15;
• ccxlviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-7;
• ccxlix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-28;
• ccl. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-29;
• ccli. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IFN-α;
• cclii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-21;
• ccliii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-2;
• ccliv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-15;
• cclv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-7;
• cclvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-28;
• cclvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-29;
• cclviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IFN-α;
• cclix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-21;
• cclx. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-2;
• cclxi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-15;
• cclxii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-7;
• cclxiii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-28;
• cclxiv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-29;
• cclxv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GD2 monoclonal antibody, and Z is IFN-α;
• cclxvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-21;
• cclxvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-2;
• cclxviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-15;
• cclxix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-7;
• cclxx. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-28;
• cclxxi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-29;
• cclxxii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-5T4 monoclonal antibody, and Z is IFN-α;
• cclxxiii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-21;
• cclxxiv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-2;
• cclxxv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-15;
• cclxxvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-7;
• cclxxvii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-28;
• cclxxviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-29;
• cclxxix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER3 monoclonal antibody, and Z is IFN-α;
• cclxxx. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-21;
• cclxxxi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-4;
• cclxxxii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-EGFR monoclonal antibody, and Z is IL-4;
• cclxxxiii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-4;
• cclxxxiv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER2 monoclonal antibody, and Z is IL-4;
• cclxxxv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-4;
• cclxxxvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-VEGFR2 monoclonal antibody, and Z is IL-4;
• cclxxxvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-4;
• cclxxxviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PDGFR monoclonal antibody, and Z is IL-4;
• cclxxxix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-4;
• ccxc. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GPC3 monoclonal antibody, and Z is IL-4;
• ccxci. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-4;
• ccxcii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PD-L1 monoclonal antibody, and Z is IL-4;
• ccxciii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-4;
• ccxciv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD19 monoclonal antibody, and Z is IL-4;
• ccxcv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-4;
• ccxcvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD20 monoclonal antibody, and Z is IL-4;
• ccxcvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-4;
• ccxcviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD22 monoclonal antibody, and Z is IL-4;
• ccxcix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-4;
• ccc. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-PSMA monoclonal antibody, and Z is IL-4;
• ccci. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-4;
• cccii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CEA monoclonal antibody, and Z is IL-4;
• ccciii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-4;
• ccciv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-BCMA monoclonal antibody, and Z is IL-4;
• cccv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-4;
• cccvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-gpA33 monoclonal antibody, and Z is IL-4;
• cccvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CD33 monoclonal antibody, and Z is IL-4;
• cccviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CD33 monoclonal antibody, and Z is IL-4;
• cccix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-4;
• cccx. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-DLL3 monoclonal antibody, and Z is IL-4;
• cccxi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-4;
• cccxii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-MUC17 monoclonal antibody, and Z is IL-4;
• cccxiii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-4;
• cccxiv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-CLDN18 monoclonal antibody, and Z is IL-4;
• cccxv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-4;
• cccxvi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-GD2 monoclonal antibody, and Z is IL-4;
• cccxvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-4;
• cccxviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-5T4 monoclonal antibody, and Z is IL-4;
• cccxix. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-4;
• cccxx. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-HER3 monoclonal antibody, and Z is IL-4;
• cccxxi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-Ebola monoclonal antibody, and Z is IL-2;
• cccxxii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-Ebola monoclonal antibody, and Z is IL-15;
• cccxxiii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-Ebola monoclonal antibody, and Z is IL-7;
• cccxxiv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-Ebola monoclonal antibody, and Z is IL-28;
• cccxxv. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-Ebola monoclonal antibody, and Z is IL-29;
• cccxxvi. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-Ebola monoclonal antibody, and Z is IFN-α;
• cccxxvii. the IL-10 is SEQ ID No:
• 1, the second antibody is an anti-Ebola monoclonal antibody, and Z is IL-21;
• cccxxviii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-Ebola monoclonal antibody, and Z is IL-2;
• cccxxix. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-Ebola monoclonal antibody, and Z is IL-15;
• cccxxx. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-Ebola monoclonal antibody, and Z is IL-7;
• cccxxxi. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-Ebola monoclonal antibody, and Z is IL-28;
• cccxxxii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-Ebola monoclonal antibody, and Z is IL-29;
• cccxxxiii. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-Ebola monoclonal antibody, and Z is IFN-α;
• or
• cccxxxiv. the IL-10 is SEQ ID No:
• 5, the second antibody is an anti-Ebola monoclonal antibody, and Z is IL-21.
• cccxxxv.