Self-assembling peptides with hyaluronic acid binding domains and methods of use thereof
AssigneeNorthwestern University
InventorsKyle Michael Koss, Terrance J. Sereda, Jason Albert Wertheim
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Abstract
Provided herein are self-assembling peptides comprising hyaluronic acid binding domains, nanofibers and systems comprising the same, and methods of use thereof.
Claims28
A self-assembling peptide comprising a plurality of BX7B domains, wherein B is a basic amino acid and X is any amino acid except an acidic amino acid, and wherein the self-assembling peptide binds to one or more extracellular matrix components.
The self-assembling peptide of any one of the preceding claims, wherein the peptide comprises 26-28 amino acids.
The self-assembling peptide of any one of the preceding claims, comprising three, four or five BX7B domains.
The self-assembling peptide of any one of the preceding claims, wherein B is a basic amino acid selected from histidine, arginine, or lysine.
The self-assembling peptide of any one of the preceding claims, wherein X is an amino acid selected from histidine, lysine, arginine, serine, threonine, asparagine, glutamine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, tyrosine, tryptophan, proline, glycine, and cysteine.
The self-assembling peptide of any one of the preceding claims, wherein the peptide has a propensity to form β-sheet secondary structure.
The self-assembling peptide of any one of the preceding claims, comprising a sequence selected from:
- (SEQ ID NO:
- 1)
- KTKATVLIKNKQKSKNALKQKIVLLSK,
- (SEQ ID NO:
- 2)
- LKTKIKIIVKTKSSAKLRSKLVNSHKI,
- (SEQ ID NO:
- 3)
- TQLRNKYTFLARARNALAVRTKQNIKS,
- (SEQ ID NO:
- 4)
- TNLRNKYTFLARARANLAVRNKQNIKS,
- and
- (SEQ ID NO:
- 5)
- KTKATVKIKNKQKSVNALKQKIVLLSK.
A nanofiber comprising a plurality of self-assembling peptides, wherein each of the plurality of self-assembling peptides comprises a plurality of BX7B domains, wherein B is a basic amino acid and X is any amino acid except an acidic amino acid, wherein the self-assembling peptide binds to hyaluronic acid.
Dependencies are inferred from the claim text.