Ethyl modified rna caps and methods of use
AssigneeNutcracker Therapeutics, Inc.
InventorsColin James McKinlay, Wan Lu Woo-Derleth
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Abstract
Provided herein are compounds that are cap analogs for polynucleotides, e.g., RNA molecules, such as mRNA molecules. Also provided are capped polynucleotides, e.g., capped RNA molecules, such as capped mRNA molecules, wherein the 5′ end of the RNA molecule comprises a cap analog disclosed herein, drug products comprising the capped RNA molecules, methods for making capped polynucleotides disclosed herein, and kits for making the capped polynucleotides.
Claims22
A compound of Formula (I), or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof:
- wherein
- X is O or S;
- R1 is OH or a polynucleotide, and
- R2 is H or Me.
A compound as shown in Table 1, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof:
- TABLE 1
- Compound ID
- Structure
- Compound 1 (Compd 1)
- Compound 2 (Compd 2)
- Compound 3 (Compd 3)
- Compound 4 (Compd 4)
(canceled)
(canceled)
Dependencies are inferred from the claim text.