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US 2025/0026770 A1Published application
Novel boronsome facilitating diagnosis and treatment
AssigneePeking University
InventorsZhibo LIU, Jiyuan LI, Zhibin GUO
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Abstract
The present disclosure provides a carborane-phospholipid conjugate, in which carboranyl is introduced at the end of the arm of a phospholipid. The present disclosure also provides a liposome composition including the carborane-phospholipid conjugate, and a use of the composition in delivering at least one therapeutic agent and/or at least one diagnostic agent.
Claims19
A carborane-phospholipid conjugate of Formula (I),
- wherein:
- one of R1 and R2 is -L-carboranyl, and the other is a linear alkyl or alkenyl group of 10-24 carbon atoms, wherein L is a divalent linking group;
- X is selected from the group consisting of —H, —CH2CH2NH3, —CH2CH2N+(CH3)3, —CH2CH(NH2)COOH, —CH2CH(OH)CH2OH, and 2,3,4,5,6-pentahydroxy-cyclohexan-1-yl;
- and
- Y is selected from the group consisting of OH and O−.
2 more elements
A liposome composition, comprising a carborane-phospholipid conjugate of Formula (I),
- wherein:
- one of R1 and R2 is -L-carboranyl, and the other is a linear alkyl or alkenyl group of 10-24 carbon atoms, wherein L is a divalent linking group;
- X is selected from the group consisting of —H, —CH2CH2NH3, —CH2CH2N+(CH3)3, —CH2CH(NH2)COOH, —CH2CH(OH)CH2OH, and 2,3,4,5,6-pentahydroxy-cyclohexan-1-yl;
- and
- Y is selected from the group consisting of OH and O−,
- wherein the conjugate a is part of a lipid bilayer.
3 more elements
Dependencies are inferred from the claim text.