Papd5 inhibitors and methods of use thereof

A compound of Formula (VIII):

• or a pharmaceutically acceptable salt thereof, wherein:
• X1 is selected from O, S, CF2, C═O, CHCl, CHF, CCl2, C═N—OH, NH, NCH3, Si(OH)2, SO2, and cyclopropylidene;
• each is independently a single bond or a double bond, provided that no more than two of are double bonds;
• R1, R2, R4, and R5 are each independently selected from H, C1-3 alkyl, C1-3 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, halo, CN, and NO2;
• W is selected from C(O)OR8 and a carboxylic acid bioisostere;
• R8 is selected from H and C1-6 alkyl;
• R3 is halo;
• and
• each R7 is independently selected from halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 haloalkoxy, and C1-3 alkoxy.