N-(5-substituted-[(1,3,4-thiadiazolyl) or (thiazolyl)])(substituted)carboxamide compounds and use thereof for inhibiting human polymerase theta

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein
• V is N or CR;
• W is optionally substituted C1-6 alkylene, optionally substituted C2-6 alkenylene, optionally substituted C2-6 alkynylene, optionally substituted C3-8 cycloalkylene, or optionally substituted C6-10 arylene;
• X is optionally substituted C2-9 heterocyclylene, optionally substituted C2-9 heteroarylene, or optionally substituted C6-10 arylene, wherein X is further optionally substituted with -L1-RX, wherein L1 is —O—, —NRX1—, optionally substituted C2-9 heterocyclylene, optionally substituted C2-9 heteroarylene, or optionally substituted C3-8 cycloalkylene, RX is optionally substituted C1-6 alkyl, optionally substituted C2-6 heteroalkyl, optionally substituted C2-9 heterocyclyl, optionally substituted C2-9 heteroaryl, optionally substituted C3-8 cycloalkyl C1-6 alkyl, or optionally substituted C2-9 heteroaryl C1-6 alkyl, and RX1 is hydrogen or optionally substituted C1-6 alkyl;
• Y is optionally substituted C2-9 heterocyclyl, optionally substituted C2-9 heteroaryl, optionally substituted C6-10 aryl;
• Z is a H, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkynyl, optionally substituted C1-6 alkoxy, optionally substituted C3-8 cycloalkyl, optionally substituted C2-9 heterocyclyl, optionally substituted C2-9 heteroaryl, or optionally substituted C6-10 aryl;
• and
• R is hydrogen, halogen, optionally substituted C1-6 alkyl, CN, optionally substituted C3-8 cycloalkyl, optionally substituted C1-6 alkoxy, optionally substituted C3-8 cycloalkoxy, N(R1)2, or C(O)NH2, wherein each R1 is independently hydrogen, optionally substituted C1-6 alkyl, or optionally substituted C3-8 cycloalkyl.