Colibactin derivatives and methods of treating, ameliorating, and/or preventing cancer

A compound of Formula (I):

• A1-B-A2 (I),
• wherein A1 and A2 are each independently selected from the group consisting of
• wherein B is a bifunctional group selected from the group consisting of:
• wherein each occurrence of R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R6a, and R6b is independently selected from the group consisting of hydrogen, deuterium, halogen, optionally substituted C1-C6 alkoxy, optionally substituted C1-C6 alkyl, and optionally substituted C3-C6 cycloalkyl;
• wherein R7 is selected from the group consisting of hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C2-C6 cycloalkenyl, and optionally substituted C2-C6 cycloalkynyl;
• wherein PG is a protective group selected from the group consisting of tert-butoxycarbonyl (Boc), trityl, dimethoxytrityl, tert-butyldimethylsilyl (TBDMS), carboxybenzyl (Cbz), nitroveratryloxycarbonyl (Nvoc), aryldithioethyloxycarbonyl (Ardec), (9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl) amino)-3-methyl-1-oxobutan-2-yl) carbamate (Fmoc-Val-Cit-PAB) and derivates thereof;
• each occurrence of R is independently H and optionally substituted C1-C6 alkyl;
• wherein each occurrence of n, n1, and n2 is independently 2, 3, 4, 5, or 6;
• and
• wherein each occurrence of n3 is independently 1, 2, 3, 4, 5, or 6;
• or a salt, solvate, isotopically labelled derivative, stereoisomer, tautomer, or geometric isomer thereof, or a mixture thereof.