Heteroaryl-linked analogs as mglu5 negative allosteric modulators and methods of making and using the same

A compound of the following formula:

• wherein B′ is a bond, —O—, or substituted or unsubstituted C1-C6 alkyl;
• C′ is a bond, or substituted or unsubstituted C1-C6 alkyl;
• wherein each R, when present, is independent and chosen from H, D, OH, ORA, F, CHF2, CF3, halogen, F, Cl, CH3, alkyl, alkyl-halogen, —O-CD3, CD3, cycloalkyl, CN, methoxy, or alkoxy;
• RA is CH3, C1-C6 alkyl, —CH2—CH2—O—CH3;
• B is
• wherein X1 is CH, C—R1, or N;
• X2 is CH, C—R1, or N;
• X3 is CH, C—R1, or N;
• X4 is CH, C—R1, or N;
• X5 is CH, C—R1, or N;
• each R1, when present, is independent and chosen from H, D, OH, NH2, N(alkyl)(alkyl), CHF2, CF3, halogen, F, Cl, CH3, alkyl, cycloalkyl, alkyl-halogen, CD3, aryl, heterocycle, CN, methoxy, or alkoxy;
• C is
• wherein X1 is CH, C—R2, or N;
• X2 is CH, C—R2, or N;
• X3 is CH, C—R2, or N;
• X4 is CH, C—R2, or N;
• X5 is CH, C—R2, or N;
• each R2, when present, is independent and chosen from H, D, OH, NH2, N(alkyl)(alkyl), CHF2, CF3, halogen, F, Cl, CH3, alkyl, cycloalkyl, alkyl-halogen, CD3, aryl, heterocycle, CN, methoxy, or alkoxy;
• or a pharmaceutically acceptable salt thereof.