Method for the industrial production of 2-halo-4,6-dialkoxy-1,3,5-triazines and their use in the presence of amines

A pair of reagents for stabilization of collagen matrices and for condensation of polymers, comprising:

• a first reagent (Reagent 1) comprising:
• a) at least one or more 2-halo-4,6-dialkoxy-1,3,5-triazines of formula III:
• wherein:
• R1 and R2 are independently —CH3, —CH2CH3, —CH(CH3)2, —(CH2)2CH3, or —(CH2)3CH3;
• and X is Cl−or Br−;
• b) a buffer selected from the group consisting of MES, ACES, BES, POPSO, TRIS, HEPPSO, TAPS and Tris-NaCitrate;
• c) an inorganic salt of formula X+Y−, wherein X+is selected from the group consisting of Na+, K+, and Ag+, and Y−is selected from the group consisting of ClO4−, BF4−, and Cl−;
• and
• d) a solvent selected from the group consisting of aliphatic ether, alcohol, water, acetone and THF, and
• a second reagent (Reagent 2) comprising:
• a) a tertiary amine selected from the group consisting of TMA (trimethylamine), TEA (triethylamine), DEMA (diethylmethylamine), NMM (N-methylmorpholine), NEM (N-ethylmorpholine), MPD (methylpyrrolidine), and MP (methylpiperidine), and/or a quaternary salt thereof;
• b) a buffer selected from the group consisting of BES, MOPS, TRIS, POPSO, TAPS and Tris-NaCitrate;
• and
• c) a solvent selected from the group consisting of aliphatic ether, alcohol, water, acetone and THE.