Process for preparation of triheptanoin
AssigneeNavinta LLC
InventorsPankaj Vasudev Parmar, John Muthiah Raja Jeyakumar, Pratish Valjibhai Dadhaniya, Miteshgir Kanchangir Goswami
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Abstract
A process is provided for the preparation of triheptanoin having a purity of greater than about 99% as measured by HPLC and/or GC. The inventive process disclosed is simple, cost effective and provides preparation of highly pure triheptanoin without the use column chromatography. The inventive process for the preparation of stable and highly pure triheptanoin involves use of adsorbing agent and at least one organic solvent during purification.
Claims20
A process for preparation of a pharmaceutically acceptable triheptanoin, comprising the steps of:
- a) reacting glycerol with heptanoic acid using at least one first organic solvent and at least one catalyst under reflux conditions;
- b) isolating crude triheptanoin;
- c) purifying the crude triheptanoin using at least one adsorbing agent and adding at least one second organic solvent, and adding a medium chain fatty acid;
- and
- d) isolating the pharmaceutically acceptable triheptanoin;
- wherein the pharmaceutically acceptable triheptanoin has a purity of about 99% or more and an acid value of about 0.2 mg KOH/gm or more.
A process for preparation of a pharmaceutically acceptable triheptanoin, comprising the steps of:
- a) reacting glycerol with heptanoic acid using at least one first organic solvent and at least one catalyst under reflux conditions at a temperature of about 140° C. or less to obtain crude triheptanoin;
- b) purifying the crude triheptanoin using at least one adsorbing agent and adding at least one second organic solvent;
- and
- c) isolating the pharmaceutically acceptable triheptanoin having a purity of at least about 99.5%.
Dependencies are inferred from the claim text.