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US 2025/0026705 A1Published application
Method for producing medetomidine and its derivatives
AssigneeObshestvo S Ogranichennoi Otvetstvennostiu "Vik-Zdorove Zhivotnykh"
InventorsDmitrii Sergeevic OREHOV, Boris Viktorovich VIOLIN
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Abstract
The invention relates to the field of pharmaceutical chemistry and discloses methods for obtaining medetomidine of formula 2 and its derivatives of formula 3 and formula 24 from starting compound 5
Claims7
Synthetic method of starting compound 5 to obtain medetomidine and its derivatives, including cobalt-catalyzed cross-coupling of substituted aryl magnesium halide 10
- with carbonyl-protected 3-bromo-2-butanone 14
- one pot deprotection to obtain 3-(2,3-dimethylphenyl)butan-2-one 7
- followed by halogenation of 3-(2,3-dimethylphenyl)butan-2-one 7 with molecular bromine to obtain the starting 1-bromo-3-(2,3-dimethylphenyl)butan-2-one 5
Dependencies are inferred from the claim text.