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US 2025/0025673 A1Published application
Method for treatment of airway stricture or stenosis
AssigneeAiriver Medical, Inc.
InventorLixiao Wang
Life of this patent
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Abstract
A method of treating a recurring airway stricture or stenosis in a body lumen includes inserting a scope and a drug-coated balloon catheter into a target site comprising the recurring airway stricture or stenosis in the body lumen. The method includes inflating the balloon to an inflation diameter such that the coating contacts an interior of the body lumen at the target site. The method includes deflating the balloon and withdrawing the scope and the balloon catheter from the target site.
Claims20
A method of treatment of a recurring airway stricture or stenosis in an airway body lumen, the method comprising:
- inserting a scope and a balloon catheter into a target site at the recurring airway stricture or stenosis in the airway body lumen, wherein the balloon catheter comprises
- an elongated balloon, and
- a coating layer overlying an exterior surface of the balloon, wherein the coating layer comprises one or more additives and an initial drug load of a therapeutic agent chosen from paclitaxel, docetaxel, taxol, rapamycin, sirolimus, zotarolimus, everolimus, tacrolimus, an analogue thereof, and a combination thereof;
- inflating the balloon to an inflation diameter such that the coating contacts an interior of the body lumen at the target site;
- deflating the balloon;
- and
- withdrawing the scope and the balloon catheter from the target site.
4 more elements
The method of claim, wherein
- the method is a method of treatment of laryngostenosis and/or subglottic stricture or stenosis, wherein the method further comprises damaging, dilating, and/or removing the laryngostenosis and/or subglottic stricture or stenosis at a target site in the body lumen;
- or
- the method is a method of treatment of severe asthma, wherein the target site comprises a mainstem bronchus, bronchus intermedius, and/or a lobar bronchus;
- or
- the method is a method of treatment of, and/or a method of reduction of exacerbation of and/or hospitalization for, severe asthma, wherein the target site comprises a trachea, mainstem bronchus, bronchus intermedius, and/or a lobar bronchus, wherein the method is free of flushing the target site, wherein the method comprises hydrating and/or soaking the coating outside the body to activate the coating;
- or
- the method is a method of reducing a concentration of bronchial smooth muscle cells of a severe asthma patient, wherein the target site comprises bronchial smooth muscle cells in a body lumen;
- or
- the method is a method of reducing a concentration of eosinophils, IL-4, IL-5, IL-6, IL-13, IL-23, and/or ILC2 in an airway tract, wherein the target site comprises a trachea, mainstem bronchus, bronchus intermedius, and/or a lobar bronchus;
- or
- the method is a method of treatment of a mucous plug in an airway, wherein the method further comprises removing mucous plug from a target site in a body lumen prior to inflation;
- or
- the method is a method of reduction of concentration of goblet cells in an airway tract, wherein the target site comprises one or more goblet cells in a body lumen;
- or
- the method is a method of reducing a concentration of one or more mucins in the airway tract, wherein the target site comprises a trachea, mainstem bronchus, bronchus intermedius, and/or a lobar bronchus.
12 more elements
Dependencies are inferred from the claim text.