Reactivation of and restoration of electrical signaling by neurons involved in controlling brain function
OwnerMichael Slatterinventor
Life of this patent
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Abstract
A system for reversing the effects of inhaled anesthesia reactivates and restores electrical signaling of neurons that control brain function of a subject. The system is used to administer increased inhaled carbon dioxide to a subject while causing an increase in the subject's respiratory rate and tidal volume and, thus, an increase in the subject's minute ventilation. The changes in the subject's respiration are tailored to increase extracellular acidification around neurons that control brain function, which have been affected by the inhaled anesthesia, and to inhibit ion channel activity (e.g., TREK-1 ion channel activity, etc.) to reactivate and restore electrical signaling by such neurons.
Claims20
A method for accelerating reversal of the effects of inhaled anesthesia on a subject once administration of the inhaled anesthesia to the subject is complete, comprising:
- causing the subject to breathe an above-ambient amount of carbon dioxide;
- increasing a respiratory rate by the subject to above a normal anesthetized respiratory rate for the subject;
- and
- increasing a tidal volume of respiration by the subject to above a normal anesthetized tidal volume for the subject,
- the causing the subject to breathe the above-ambient amount of carbon dioxide, the increasing the respiratory rate, and the increasing the tidal volume together tailored to inhibit TREK-1 ion channel activity in and to restore electrical signaling by neurons involved in controlling brain function including consciousness and respiration of the subject.
A method for accelerating reversal of the effects of inhaled anesthesia on a subject once administration of the inhaled anesthesia to the subject is complete, comprising:
- causing the subject to rebreathe exhaled carbon dioxide;
- increasing a respiratory rate by the subject to at least 10 breaths per minute;
- and
- increasing a tidal volume of respiration by the subject to at least 8 mL/kg of body weight of the subject.
A system for accelerating reversal of the effects of inhaled anesthesia on a subject once administration of the inhaled anesthesia to the subject is complete, comprising:
- a ventilator that ventilates the subject at a respiratory rate that exceeds a normal anesthetized respiratory rate for the subject and at a tidal volume that exceeds a normal anesthetized tidal volume for the subject;
- a breathing circuit that establishes communication between the ventilator and the subject;
- and
- an anesthesia reversal device in communication with the breathing circuit in a manner that causes the subject to inhale an above-ambient amount of carbon dioxide,
- with the ventilator and the anesthesia reversal device causing the subject to breathe in a manner that inhibits ion channel activity in and restores electrical signaling by neurons involved in controlling brain function including consciousness and respiration of the subject.
Dependencies are inferred from the claim text.