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US 2025/0025602 A1Published application
Use of Resected Liver Serum for Whole Liver-Engineering
AssigneesMiromatrix Medical Inc., Mayo Foundation for Medical Education and Research
InventorsJeffrey ROSS, Anne YOUNG, Allie HAARSTAD, Scott NYBERG
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Abstract
The disclosure provides a method of using blood or fractions thereof, e.g., serum, obtained from a mammal subjected to liver surgery, for example, obtained following a partial hepatectomy, to increase the engraftment, proliferation and/or functionality of cells on a biocompatible scaffold.
Claims23
1-20. (canceled)
A composition comprising:
- a) a substrate;
- b) a plurality of cells comprising cholangiocytes and at least one of hepatocytes, endothelial cells, stem cells or any combination thereof;
- and
- c) an aqueous media comprising blood or a fraction thereof isolated from a mammal subjected to a liver surgery.
1 more element
A composition comprising:
- a) an at least partially recellularized isolated extracellular matrix of a liver or a portion thereof comprising a plurality of cells comprising cholangiocytes and at least one of hepatocytes, endothelial cells, stem cells or any combination thereof, and
- b) an aqueous media comprising blood or a fraction thereof isolated from a mammal subjected to liver resection.
Dependencies are inferred from the claim text.