Pneumatospun biopolymer scaffolds and methods for their production
AssigneeScripps Health
InventorsDarryl D. D'LIMA, Erik W. DORTHE, Austin B. WILLIAMS, Shawn P. GROGAN
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Abstract
Disclosed herein are methods of producing a scaffold by producing a biopolymer scaffold composition by pneumatospinning a polymer solution comprising polymer fibers onto a collector; feeding the polymer fiber solution comprising the polymer fiber into an air brush; applying a gas pressure around the polymer fiber solution comprising the polymer fiber in the airbrush; ejecting the polymer fiber from the air brush onto the collector; crosslinking the polymer fibers; and seeding a plurality of cells to the polymer scaffold composition.
Claims36
A method comprising:
- a) applying a gas pressure around a polymer fiber solution comprising a polymer fiber to eject the polymer fiber solution;
- and
- b) collecting the polymer fiber by a collector to form a scaffold,
- wherein the scaffold is suitable for use as a meniscal repair device, and
- wherein the collector comprises a shape of a meniscus.
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-48. (canceled)
A method comprising:
- a) applying a gas pressure around a polymer fiber solution comprising a polymer fiber to eject the polymer fiber solution;
- and
- b) forming a scaffold comprising the polymer,
- wherein the scaffold is suitable for use as a meniscal repair device, and
- wherein the scaffold has a thickness of at least about 300 micrometer (μm) and a porosity of at least about 40%.
-99. (canceled)
A method comprising:
- a) applying a gas pressure around a polymer fiber solution comprising a plurality of polymer fibers to eject the polymer fiber solution;
- b) rotating a collector;
- c) collecting at least a subset of the plurality of polymer fibers onto a surface of the collector to form a scaffold;
- and
- d) crosslinking the at least the subset of the plurality of polymer fibers,
- wherein the scaffold is suitable for use as a meniscal repair device, and
- wherein the collector is rotated on an axis co-linear to an ejection path of a).
-158. (canceled)
Dependencies are inferred from the claim text.