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US 2025/0025599 A1Published application
Embolic compositions and methods
AssigneeArsenal Medical, Inc.
InventorsJeffrey Groom, Craig Wiltsey, Quynh Pham, Nikhita Mansukhani, Courtney Guertin, Lee Core, Upma Sharma
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Abstract
The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.
Claims15
A method of embolizing a hypervascular tumor in a patient in need thereof, the method comprising:
- (a) forming a crosslinkable composition for vascular embolization comprising:
- (i) providing a first fluid composition comprising (A) a crosslinkable polymer and (B) a first imaging agent having an average primary particle size from 80 nm to 200 nm;
- (ii) providing a second fluid composition comprising (A) a crosslinker and, optionally, (B) a second imaging agent having an average primary particle size from 80 nm to 200 nm;
- and
- (iii) mixing the first fluid composition and the second fluid composition with a dry composition, the dry composition comprising a first silica filler and, optionally, a second silica filler that is the same or different from the first silica filler;
- thereby forming the crosslinkable composition, wherein the first imaging agent, the second imaging agent, the first silica filler, and the optional second silica filler are dispersed in the crosslinkable composition;
- (b) preparing the crosslinkable composition for injection;
- and
- (c) injecting the crosslinkable composition into an injection site within a vasculature of the hypervascular tumor whereupon the crosslinkable composition substantially flows into and occludes a target vessel in the vasculature, and whereafter the crosslinkable composition crosslinks and forms into a solid.
6 more elements
Dependencies are inferred from the claim text.