Recombinant aav capsid proteins
AssigneeVectorY B.V.
InventorsBarbara Sanders, Wouter Pos, Pavlina Konstantinova, Sander Van Deventer
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Abstract
Provided herein are recombinant adeno-associated virus (AAV) capsid proteins, compositions (e.g., rAAV) comprising the capsid proteins, nucleic acids encoding the capsid proteins, and methods of making and using the capsid proteins.
Claims117
A recombinant adeno-associated virus (AAV) capsid protein comprising a peptide and a parental capsid protein, wherein the peptide is comprised within loop IV and/or loop VIII of the parental capsid protein, and wherein the peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-9.
A recombinant adeno-associated virus (AAV) capsid protein comprising a first peptide, a second peptide, and a parental capsid protein, wherein the first peptide is comprised within loop IV of the parental capsid protein and the second peptide is comprised within loop VIII of the parental capsid protein, and wherein the first peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-9, 35, and 36 and the second peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-9, 35, and 36.
Dependencies are inferred from the claim text.