Compositions and Methods for Cell-Specific Expression of Target Genes
AssigneeThe Trustees of Princeton University
InventorsCarola Maturana, Esteban Engel
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Abstract
Provided are polynucleotides comprising a transcriptional control element comprising a promoter sequence having at least 80% sequence identity to SEQ ID NO: 1. SEQ ID NO:2. SEQ ID NO:3 or SEQ ID NO:4 and a cell- or tissue-specific enhancer element. Also provided are compositions (e.g., vectors, viruses, host cells, and pharmaceutical compositions) comprising said polynucleotides, methods that are useful for expressing a target gene in a host cell, and methods that are useful for expressing a target gene in a subject in need thereof.
Claims49
A polynucleotide comprising a transcriptional control element, wherein the transcriptional control element comprises a promoter sequence having at least 80% sequence identity to SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 or SEQ ID NO:4 and a cell- or tissue-specific enhancer element.
Dependencies are inferred from the claim text.