US 2025/0025571 A1 · ANTI-CD37 ANTIBODY-DRUG CONJUGATE

Abstract

It is an object to provide an antibody specifically binding to CD37-positive tumor cells such as malignant B-cell lymphoma, an antibody-drug conjugate comprising the antibody, a pharmaceutical composition having therapeutic effects on a tumor using the antibody, a method for treating a tumor using the aforementioned pharmaceutical composition, a method for producing the antibody, and a method for producing the antibody-drug conjugate, and the like. The present invention provides an anti-CD37 antibody-drug conjugate in which an antibody is conjugated to a drug linker represented by the following formula (wherein A represents a connecting position to the antibody) by a thioether bond, specifically, a humanized anti-CD37 antibody having internalization ability and an antibody-drug conjugate containing the antibody.

Claims33

Dependent claims

An anti-CD37 antibody comprising:

a light chain variable region comprising the amino acid sequence at positions 21 to 128 in the light chain full-length amino acid sequence shown in SEQ ID NO:
2 or an amino acid sequence having a homology of 90% or more to the amino acid sequence at positions 21 to 128 in the light chain full-length amino acid sequence shown in SEQ ID NO:
2, and
a heavy chain variable region comprising the CDRH1 consisting of SEQ ID NO:
22;
the CDRH2 consisting of SEQ ID NO:
23;
and the CDRH3 consisting of SEQ ID NO:
24

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/907,786Filed 7 Oct 2024

Priority

JP 2021-17011418 Oct 2021

Published

23 Jan 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

A61K 47/6849
The modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site: the antibody targeting a receptor, a cell…
A61K 31/4745
Ortho- or peri-condensed with heterocyclic ring systems: condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
A61K 39/395
Medicinal preparations containing antigens or antibodies: antibodies ; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 45/00
Medicinal preparations containing active ingredients not provided for in groups a61k31/00 -

Anti-cd37 antibody-drug conjugate

Life of this patent

Anti-cd37 antibody-drug conjugate

Life of this patent

Abstract

Claims33