Tissue-specific imaging and therapeutic agents targeting proteins expressed on muscle cell surface

A method of treating a pathology in an individual, comprising administering to the individual a therapeutically effective amount of a therapeutic targeting agent that specifically or selectively binds a targeted protein expressed on muscle tissue cell surface;

• wherein the targeted protein is enriched in muscle tissue relative to other tissues;
• wherein the targeted protein has stable or increased expression in diseased tissue relative to otherwise comparable normal tissue;
• and
• optionally wherein the targeted protein is internalized and recycled within from about 2 minutes to about 12 hours, from about 2 minutes to about 10 hours, from about 2 minutes to about 8 hours, from about 2 minutes to about 6 hours, from about 2 minutes to about 4 hours, from about 2 minutes to about 2 hours, from about 2 minutes to about 60 minutes, from about 2 minutes to about 40 minutes, from about 2 minutes to about 20 minutes, from about 2 minutes to about 10 minutes, from about 10 minutes to about 12 hours, from about 20 minutes to about 12 hours, from about 40 minutes to about 12 hours, from about 60 minutes to about 12 hours, from about 2 hours to about 12 hours, from about 4 hours to about 12 hours, from about 6 hours to about 12 hours, from about 8 hours to about 12 hours, from about 10 hours to about 12 hours, or from about 11 hours to about 12 hours;
• thereby treating the pathology in the individual.

A method of delivering an imaging agent to muscle tissue in a tissue-specific or tissue-selective manner, comprising contacting the surface of muscle cell(s) of the muscle tissue with an effective amount of an imaging agent that comprises an imaging agent component and a targeting agent component, wherein the targeting agent component specifically or selectively binds to a targeted protein expressed on the cell surface of the muscle cells of the muscle tissue;

• wherein the targeted protein is enriched in muscle tissue relative to other tissues;
• wherein the targeted protein has stable or increased expression in diseased tissue relative to otherwise comparable normal tissue;
• and
• optionally wherein the targeted protein is internalized and recycled within from about 2 minutes to about 12 hours, from about 2 minutes to about 10 hours, from about 2 minutes to about 8 hours, from about 2 minutes to about 6 hours, from about 2 minutes to about 4 hours, from about 2 minutes to about 2 hours, from about 2 minutes to about 60 minutes, from about 2 minutes to about 40 minutes, from about 2 minutes to about 20 minutes, from about 2 minutes to about 10 minutes, from about 10 minutes to about 12 hours, from about 20 minutes to about 12 hours, from about 40 minutes to about 12 hours, from about 60 minutes to about 12 hours, from about 2 hours to about 12 hours, from about 4 hours to about 12 hours, from about 6 hours to about 12 hours, from about 8 hours to about 12 hours, from about 10 hours to about 12 hours, or from about 11 hours to about 12 hours;
• thereby delivering an imaging agent to muscle tissue in a tissue-specific or tissue-selective manner