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US 2025/0025552 A1Published application
Pro-Inflammatory and Adjuvant Functions of Toll-Like Receptor 4 Antagonists
AssigneeChildren’s Medical Center Corporation
InventorJonathan C. Kagan
Life of this patent
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Abstract
The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.
Claims21
-25. (canceled)
A method for inducing or enhancing an adaptive immune response to an infectious agent in a subject in need thereof, the method comprising:
- administering a therapeutically effective amount of (i) a toll-like receptor (TLR) 4 agonist, a TLR2 agonist, and/or a TLR9 agonist;
- (ii) an oxidated 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (oxPAPC) species;
- and (iii) an immunogen from an infectious agent to the subject.
Dependencies are inferred from the claim text.