Kexin-derived vaccines to prevent or treat fungal infections
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsJay K. Kolls, Michael Zheng, Karen Norris, Heather Kling
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Abstract
A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine may be used to prevent or to treat fungal infections. The novel vaccine can provide protective immunity, even for immunocompromised individuals such as HIV patients having reduced levels of CD4+ T cells.
Claims29
The protein mini-Kexin (SEQ ID NO 5).
A fusion protein that comprises mini-Kexin (SEQ ID NO 5), but that does not comprise the entire Kexin protein;
- and that further comprises a leader that promotes secretion of said fusion protein from a mammalian cell.
Dependencies are inferred from the claim text.