Materials and methods for preventing or reducing toxicity to organophosphates and other toxic materials
AssigneeQuorum Innovations, LLC
InventorsNICHOLAS T. MONSUL, EVA A. BERKES, KAROL GLINIEWICZ, YU-HSIEN LIAO, I-FANG HSIN
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Abstract
The present invention provides materials and methods for alleviating organophosphate toxicity. More specifically, the invention provides pharmaceutical compositions comprising a protein, and/or biologically-active fragments and variants thereof, and methods of using the same.
Claims17
A method for alleviating toxicity caused by a toxin wherein said method comprises administering, to a subject in need of alleviation of such toxicity, a protein that comprises an amino acid sequence selected from:
- i) SEQ ID NO:
- 1;
- ii) a variant of SEQ ID NO:
- 1;
- and
- iii) a fragment of i) or ii) wherein said variant or fragment reduces toxicity.
A method for assessing toxicity caused by an organophosphate wherein said assay comprises administering an organophosphate to a rabbit eye ex vivo an organophosphate and measuring, in the rabbit eye, miosis and AChE enzymatic activity, wherein the presence of miosis and a reduction of AChE enzymatic activity indicates organophosphate toxicity.
A method for alleviating toxicity caused by a toxin wherein said method comprises administering, to a subject in need of alleviation of such toxicity, a composition that comprises a Lactobacillus fermentum bacterium grown in a biofilm phenotype and/or an extract from said L. fermentum and/or said biofilm.
Dependencies are inferred from the claim text.