Microbe-based modulation of serotonin biosynthesis
AssigneeThe Regents of the University of California
InventorsElaine Hsiao, Jessica Yano
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Abstract
Methods and compositions that can be used to modulate serotonin level in a subject are disclosed herein. In some embodiments, the methods include adjusting the composition of gut microbiota in the subject. Also disclosed are methods of adjusting the level of one or more serotonin-related metabolites to modulate serotonin biosynthesis in a subject, and methods for treating serotonin-related diseases, for example disorders caused by serotonin deficiency.
Claims22
A method for modulating the level of serotonin in a subject, comprising:
- adjusting the composition of gut microbiota in a subject, and thereby changing the level of serotonin in the subject.
A method for modulating serotonin biosynthesis in a subject, comprising:
- determining the level of one or more serotonin-related metabolites in a subject;
- and
- adjusting the level of at least one of the one or more serotonin-related metabolites in the subject, and thereby modulating serotonin biosynthesis in the subject.
(canceled)
A method for treating a disorder caused by serotonin deficiency, comprising:
- adjusting the composition of gut microbiota in a subject suffering from a disorder caused by serotonin deficiency;
- and
- increasing the colonic or blood level of serotonin in the subject.
22-27. (canceled)
Dependencies are inferred from the claim text.