Induction of trained immunity for the treatment of hyperproliferative disorders

Abstract

In certain embodiments, the present invention provides a method of treating a pancreatic disorder comprising administering a β-glucan. In certain embodiments, the present invention provides a method inducing influx of immune cells to a pancreas comprising administering a yeast-derived particulate β-glucan. In certain embodiments, the present invention provides a method of reducing tumor in a pancreas comprising administering a β-glucan. In certain embodiments, the present invention provides a method of recruiting anti-tumor, innate immune cells comprising administering a β-glucan. In certain embodiments, the present invention provides a method of inducing whole β-Glucan particles trained immunity in a cancer. In certain embodiments, the present invention provides a method of inhibiting cancer metastasis comprising administering WGP. In certain embodiments, the present invention provides a method of developing trained innate immune cells as an adoptive cell therapy in cancer. In certain embodiments, the present invention provides isolated or purified beta-glucan-trained innate immune cells.

Dependencies are inferred from the claim text.