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US 2025/0025489 A1Published application
Methods of vaccination in premalignant settings
AssigneeUniversity of Miami
InventorsEli GILBOA, Greta GARRIDO, Brett SCHRAND, Agata LEVAY
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Abstract
The present invention relates, in part, to methods of generating immune responses in subjects that have a likelihood of developing cancer.
Claims29
A method of treating cancer in a subject need thereof, comprising administering an effective amount of an immune-modulating agent to the subject's cancer cells to direct a subject's existing immune response to a neoantigen against the cancer, wherein:
- the immune-modulating agent inhibits and/or downregulates a mediator of antigen processing and induces neoantigen formation;
- and
- the subject has an existing immune response against the induced neoantigen.
A method for treating or preventing a cancer in a subject comprising administering, in order:
- (a) a therapeutically effective amount of the immune-modulating agent to said subject in need of such treatment, wherein the human subject has developed or is susceptible to developing cancer and wherein the immune-modulating agent stimulates a neoantigen-directed immune response in the subject, and
- (b) a different immune-modulating agent than step (a) to the subject's tumor to stimulate the same neoantigens as step (a) and direct the subject's neoantigen-directed immune response against the tumor.
Dependencies are inferred from the claim text.